Rachel McAdams as Della Frye
Ben Affleck as Stephen Collins
Russell Crowe as Cal McCaffrey
J as on Bateman
Robin Wright Penn as Anne Collins
Helen Mirren as Cameron Lynne
Jeff Daniels as George Fergus
Viola Davis as Dr. Joy Jackson
Maria Thayer as Sonia Baker
Wendy Makkena as Greer Thornton
David Harbour as Red-Six
Brianna Womick as Bobbie's waitress
Harry Lennix as Donald Bell
Rob Benedict as Milt
Katy Mixon as Rhonda Silver
Bonita Friedericy as Ms. Buzzkill
Eileen Grubba as Peggy
Zoe Lister Jones as Jessy
Gregg Binkley as Ferris
Christopher Thornton as Mr. Wheelchair
Brenda Goodbread as Metro News Reporter
Arabella Field as Mrs. Phillips
Cornell Womack as Jr. Detective
Brennan Brown as Andrew Pell
Pamela Fischer as Fergus' Organizer
Dan Brown as Vernon Sando
Jennifer Rouse as Politician
Aurelius DiBarsanti as Doctor
Michael Berresse as Robert Bingham
Matt Gulbranson as Collins' Driver
Larry Carter as Senator
Robert Bizik as Physician
David E. Goodman as Graves
Sarah Lord as Mandi Brokaw
Nick Schutt as Actor
Kimrie Lewis as Nurse
John G. Pavelec as Senator at Kennedy Center
Matthew Cannon as Young Detective
Michael Ray Reed as Sailor
Rick Hickman as Congressman in Restroom
Lance Strumpf as Helicopter Pilot
Jonathan Rackman as Mail Clerk
Carolyn Barrett as Policewoman escorting Della
Mariano Gowland as Politician