Kate Beckinsale as Amy
Robert De Niro as Frank
Sam Rockwell
Drew Barrymore
Katherine Moennig as Jilly
Melissa Leo
James Frain as Tom
Brendan Sexton III as Young Man
Lily Mo Sheen as Young Amy
Seamus Davey-Fitzpatrick as Young Robert
Mackenzie Milone as Young Rosie
Ben Schwartz as Tom
Steve Antonucci as Commuter
Stephanie Scionti as Girl in Airport
Lucian Maisel as Jack
Chandler Frantz as Young David
Lou Carbonneau as Barbeque Salesman
E.J. Carroll as Super Store Assistant Manager
Ken Sladyk as Max - Aircraft Ground Crew
Debargo Sanyal as Steff
Cheryl Woolsey as Jillian / Ticket Agent
Kelly McAndrew as Hooker
Marty Garcia as Rushed Traveler
Mandell Butler as Bellhop
Tom Feige as Train P